Togni reagent II

CAS 887144-94-7, Cat. No EN300-136055

Reagent for the nucleophilic introduction of trifluoromethyl groups

Togni reagent II (1-Trifluoromethyl-1,2-benziodoxol-3(1H)-one) is a highly effective electrophilic trifluoromethylating reagent. It is offer trifluoromethylation of carbon- and sulfur-centered nucleophiles, copper-catalyzed trifluoromethylation of unactivated olefins, trifluoromethylation of phenol derivatives, zinc-mediated formation of trifluoromethyl ethers from alcohols. Togni reagent II has a predictable positional selectivity and a high level of functional group compatibility. But despite simple procedure and mild reaction conditions, the reagent has explosive properties that are important to remember when working with it.

Synonyms: 1-(Trifluoromethyl)-1,2-benziodoxol-3(1H)-one, 1-Trifluoromethyl-1,2-benziodoxol-3(1H)-one, 1-Trifluoromethyl-1,2-benziodoxol-3-(1H)-one