tert-Butyl Isocyanide

CAS 7188-38-7, Cat. No EN300-300704

Reagent for various heterocycles synthesis, mild esterification

tert-Butyl isocyanide is a key regent for the synthesis of many heterocycles and can undergo many cyclization reactions. It is a colorless liquid, with a strong smell, bench-stable, and soluble in most organic solvents, including methanol, ethanol, ether, toluene, and dichloromethane. Many combinations of 5-member heterocycles with C, N, S, and O atoms, and even there are reports of Boron-containing cycles can be done via [4+1] cycloaddition. Except for heterocycles, the reagent finds its usage as a mild esterification reagent, especially in the chemistry of β-lactam antibiotics, penicillins, and cephalosporins. The Passerini reaction with α-geminal polyhalogenated aldehydes allows for easy esterification of such complex substrates.

Synonyms: 2-Isocyano-2-methylpropane (ACI); tert-Butyl isocyanide (6CI, 7CI, 8CI);1,1-Dimethylethyl isocyanide; 1-tert-Butylisonitrile; t-Butylisocyanide; t-Butylisonitrile; tert-Butylisonitrile