HATU

CAS 148893-10-1, Cat. No EN300-49821

Reagent for generation of an active ester from a carboxylic acid

HATU (Hexafluorophosphate Azabenzotriazole Tetramethyl Uronium) is a gold standard reagent in the field of peptide coupling, the primary purpose of which is to generate an active ester from carboxylic acid. Typically, it is used in DMF with Hünig's base (or TEA) to form an amide bond. No heating is required. By itself, HATU is a white powder, that is stable, and soluble in the polar aprotic solvent. It performs well in the case of hindered substrates when another coupling reagent can fail. This all makes HATU an excellent choice when you need a guarantee of a good result on a small scale because for a big scale, the price of HATU makes it too expensive.

Synonyms: : O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, 3-oxide, hexafluorophosphate(1-) (1:1) (ACI), 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide (9CI), 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate